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There's One Major Downside To The Keto Diet That No One Is Talking About

And it's kinda problematic if you're looking to lose weight. - by Lucy Bode
  • 05 Sep 2018
There's One Major Downside To The Keto Diet That No One Is Talking About
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It’s had Halle Berry, Gwyneth Paltrow and the Kardashian clan singing its praises. But if this new study is anything to go by, there’s one major reason to give the high-fat, low-carb keto diet a miss.

The research – published in the journal Science Translational Medicine – found that when mice were fed a high-fat diet, they were more likely to overeat. This is because they started producing a hormone called MMP-2, which essentially blocks leptin from binding to its receptors (FYI: leptins job is to inform the brain that your stomach is full.) 

RELATED: Why the ‘Square Meal Rule’ Is A Total Game Changer For Weight Loss

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The researchers believe these findings explain why leptin resistance is so common among patients with obesity. In fact, they hope that in the future clinicians will be able to treat this condition by blocking the MMP-2.

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That said, the study has its limitations: the type of fat the mice were fed wasn’t disclosed (i.e, whether it was monounsaturated fats like avo, nuts and olive oil or unhealthy saturated or trans fats.) Of course, more research on humans is needed too:

“We opened a new field of study for metabolic disease,” said Rafi Mazor, a research scientist at the University of California San Diego and the study’s lead author. 

“We need to ask what other pathways, in addition to leptin and its receptors, undergo a similar destructive process and what the consequences might be.”

RELATED: 'I Tried The Keto Diet For 3 Weeks – Here's What Happened'

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Lucy Bode
Lucy Bode
Lucy is Women Health’s digital editor, social media specialist and the go-to girl for all things holistic wellness. Her background as a journalist and passion for food, fitness and integrative medicine has led her to write for some of Australia’s leading publications over the course of her career.

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